Medicine, Health & Food

Medicine, Health & Food

Archive
Join as an Editor/Reviewer

Potential Neurogenesis and Neuroprotective Effects of Epigallocatechin-3-gallate (EGCG) in Green Tea (Camellia sinensis) Through Microglia M2 Induction Process and NLRP3 Inhibition as an Innovation for Ischemic Stroke Adjuvant Therapy: A Review

Volume: 92  ,  Issue: 1 , January    Published Date: 02 January 2022
Publisher Name: IJRP
Views: 375  ,  Download: 313 , Pages: 45 - 52    
DOI: 10.47119/IJRP100921120222656

Authors

# Author Name
1 Innas Safira Putri
2 Tazkia Nafs Robbani
3 Dinda Divamillenia
4 Octaviana Galuh Pratiwi
5 Reny I’tishom

Abstract

Stroke is a condition that results from the obstruction or rupture of blood arteries in the brain, cutting off blood flow to the brain and causing the death of brain cells. Stroke is divided into two types based on the cause: ischemic stroke and hemorrhagic stroke. Ischemic stroke is the most common kind of stroke, accounting for around 87% of all strokes. The high occurrence of ischemic stroke has a wide-ranging influence on society. Because ischemic stroke still has a high prevalence and limited treatment options, a therapeutic breakthrough that can assist reduce mortality and morbidity from stroke, particularly ischemic stroke, is needed. Consuming green tea (Camellia sinensis), which has neurogenetic and neuroprotective benefits, is one of the advances that can be used. This literature was compiled through online searches using Pubmed, Sciencedirect, NIH NCBI, and Google Scholar instruments. It is known that green tea with the active ingredient Epigallocatechin-3-gallate (EGCG) has the potential to induce neurogenesis in ischemic conditions by inducing microglia to polarize to M2 and can inhibit pro-inflammatory mediators through inhibition of NOD-like Receptor Protein-3 (NLRP3) so that the pyroptosis process will also be inhibited, in this way EGCG also has the potential to become an ingredient that provides a neuroprotective effect. These two major processes will aid in the recovery of ischemic stroke patients.

Keywords

  • neurogenesis
  • ischemic stroke
  • egcg
  • green tea
  • camelia sinensis
  • m2 microglia
  • NLRP3
  • neuroprotective