Background: Psychosis is a serious mental illness with an incidence of roughly 7 per 1000 Indonesians in 2018. With Indonesia's diverse cultures, one of them is the classification of psychotic patients as "mad people," as well as therapy efforts to visit kyai, or wise people. Objective: A case study of the Bani Amrini House in Bangkalan, Madura, Indonesia, which used a spiritual therapy strategy to treat schizophrenic patients. Discussion: The Madurese community's culture, which is predominantly Islamic, believes in using a spiritual method to heal diseases, particularly mental disorders. Prayer, dhikr, istighfar, reading the Al-Qur'an, and mindfulness are all examples of spiritual approaches in Islam. According to scientific evidence, the spiritual approach can reduce anxiety, boost calm, improve well-being, and stimulate the "happy hormone" or endorphins, all of which can assist persons with schizophrenia improve their clinical symptoms. Conclusion: Spiritual therapy approaches can be introduced by considering the appropriateness of the place and/or local culture, as well as the necessity for educational approaches to minimize stigma, improve psychotic symptoms, and improve patients quality of life.