This research study determined the extent of Teachers Participation in Online Professional Development Course, 21st century teaching skills and performance. The researcher utilized the descriptive and correlational design. The respondents of the study were 100 regular teachers of different elementary schools regardless of teaching experience. The researcher utilized the complete enumeration sampling. Mean and Pearson r moment correlation was used to analyze the data. The teachers Participation in online professional development course was rated high.  The 21st century Skills and teaching performance were rated high. The instructional competence of the teachers online professional development described as High. Self-management obtained was described as high. Teachers joined the learning course in order to address their needs in relation to the technological advances and changing educational trends of the 21st century teaching. Most of the teachers have manifested the different 21st century skills needed to address the 21st century teaching. They have great performance such as enhancement of self-worth, maintaining their set goals and targets, engaging in a continuous learning process and improve the delivery of basic education