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Protective effects of mobola plum seed extracts against paracetamol and carbon tetrachloride-induced liver damage.

Volume: 48  ,  Issue: 1 , March    Published Date: 13 April 2020
Publisher Name: IJRP
Views: 691  ,  Download: 436

Authors

# Author Name
1 Omowumi grace sedara
2 fasuhanmi oluwagbemiga samuel

Abstract

Parlnari curatellifolia has been found implicated in the treatment of diabetics, hypertention and liver disorders. The effects of aqueous and methanolic extracts on paracetamol (PCM) and Carbon tetrachloride (CCl4)-induced liver damage were investigated, with a view to utilizing the extract of the plant in the management and treatment of liver disorders. Parinari curatellifolia seeds were air-dried, soaked in water and methanol, filtered, and rotary evaporator was used to remove the methanol and freeze-dried. The extracts were screened for their phytochemical constituents. The animals were grouped into five (5) groups of four (4) animals each for both aqueous and methanolic extract using PCM and CC14 hepatotoxins. Group 1 served as control; group 2 (the hepatotoxin group); group 3 (the extract only group); group 4 (the extract (either aqueous or methanolic) + hepatotoxin group) and Group 5 (the silymarin (standard drug) + the extract group). The extracts were administered for a period of seven days. Animals were sacrificed twenty-four hours after the last administration. Pytochemical screening revealed the presence of saponins, alkaloids, flavonoids, phlobatannins, and tannins in the extracts. The results showed that paracetamol and CCU caused significant (p<0.05) decreases in the activities of liver alkaline phosphatase (ALP), L-aspartase aminotransferase (AST), L-alanine aminotransferase (ALT) and concentration of total protein, total bilirubin, urea and albumin in the liver as compared with their control. Treatment with aqueous extract and silymarin ameliorated the effect of paracetamol and CC14. The results of the histopathological study on paracetamol and CCl4 intoxicated tms revealed that the livers of the control animals were essentially normal while there were severe perinuclear vacualation of the hepatocytes in the paracetamol and CCl4 intoxicated rat fivers. In animals that received aqueous and methanolic extracts only, livers were essentially normal. Treatment with aqueous and methanolic extracts of the P. curatellifolia seed at a dosage of 600 mg/kg(bwt) reversed the effect of paracetamol and CCl4 in the serum. In conclusion, the results of the work therefore suggested that the extracts of P. curatellifolia possess hepatoprotective effects against paracetamol and CCl4 -induced liver damage in albino rats. The protection compares well with that of silymarin, (reference drug). The extracts protect the liver damage via antioxidative mechanism

Keywords

  • liver damage
  • Carbon tetrachloride
  • Paracetamol
  • Mobola plum