This study aims to examine the effects of independent variables, which are job satisfaction and job involvement on the dependent variable, which is organizational commitment of nurses. The lack of human resources or medical personnel in hospitals causes delays in treating patients. In carrying out their duties, nurses must work effectively in order achieve the expected goals of hospital management. Apart from that, the hospital plays a role so that every hospital policy can be followed by the nurses by facilitating these nurses in the form of compensation, work environment, and other facilities. The benefits of meeting these needs will lead to the behavior of providing professional services in treating patients. Satisfaction can occur because it is based on the size of the organization that affects job satisfaction. Apart from that, the presence of satisfaction leads to positive engagement so that it reflects the general cognitive state of a person who identifies themself with their work with the main goal of determining their self-image at work so that later they will be committed to their workplace. The participants of this study amounted to 100 nurses with the details of female nurses as many as 65 people and male nurses as many as 35 people working in hospitals and health centers in the Jabodetabek area and several other cities. The main analysis technique used is the multiple regression analysis. The results of this study found that there was an effect of job involvement and job satisfaction on the organizational commitment of nurses "with a significance value of 0.000 (p?0.050) with an F value of 88,589 and an R Square value of 0.637, which means that job satisfaction and work involvement jointly affect to the organizational commitment of nurses.