The purpose of this paper is to review systematically serialization process evaluation. Generally, pharmaceutical drug serialization is a regulatory compliance adopted by major countries for fighting against pharmaceutical drugs counterfeiting. Since 19th century, the drug counterfeiting is major problem for healthcare industry. Periodically, the regulatory and healthcare agencies are struggling to mitigate the risk of adverse events caused by the counterfeit drugs. The World Health Organization (WHO) has estimated that 4 out of 10 drugs available in poor or under developing countries are potentially adulterated. Ultimately, the drug manufacturers are losing billions of dollars every year due to stolen, diverted and counterfeit drugs. Currently, the regulatory authorities are adopting the stringent guidelines to restrict criminals to supply and divert counterfeit/stolen medicine in the supply chain. Healthcare industry need rigorous regulations and secure traceability technologies to provide safe and genuine drugs to the patients. Basically, the pharmaceutical drug serialization reveals advantages by improving the drug security in supply chain by reducing adverse events and investigations. Further, pharmaceutical drug serialization is based on tracking and tracing technological capabilities which leverage the benefit of tracing individual drug package in supply chain.