Systemic Inflammatory Response Syndrome (SIRS) is an early sign before sepsis with signs of fever or hypothermia, tachycardia, and leukocytosis or leukopenia. Sepsis can lead to Multiple Organ Dysfunction (MODS) even death. Almost 3 million children under 5 years of age died because of sepsis. The objective of this study is to provide a review regarding the epidemiology of SIRS in children. The prevalence of SIRS in children is common. Therefore, there still need research on the pediatric SIRS topic so that people can aware more about SIRS as a warning sign of sepsis as one of the global burden deaths that can lead to death.