The purpose of this paper is to study relationship between Organizational commitment, and performance of Health Centre IV workers in greater Mbarara District, South Western Uganda. The constructs of organizational commitment include; affective, continuance and normative. This study used cross-sectional, explanatory and correlational approaches, and it uses health center IV workers data that were collected by means of a questionnaire survey from a sample of 200 health workers from 11 health centres from the region. Structural equation modelling was used to test hypotheses. Results suggested that affective and continuance organizational commitments, were significantly associated with health workers performances (r=.384, p=.000).Normative organizational commitment, construct do not significantly predict health workers performance. Therefore, health centres IV should have appropriate practices of ensuring attachment of health workers to their health facilities, so as to perform activities that enhance on their task/job performance.