This paper examines the worsening graduate unemployment phenomenon in Ghana considering the negative effects associated with this setback and strategies that can be adopted to address them. Library research is the method used to collect the data. Globally, more graduates are found to be youthful but are plagued with the problems of unemployment, and Ghana is of no exception. This paper observes that the graduates have something to offer but have no jobs and are faced with the harsh realities of life. Ghana is not insulated to the negative effects associated with unemployment like armed robbery, prostitution, cybercrime and others. The paper recommends that instituted policies must aim at innovating Ghana's educational curriculum to make it more entrepreneurial, the government creating opportunities to empowering the youth, private enterprises creating more jobs, and the unemployed graduates themselves being creative and not waiting for the government and co-operate bodies to offer them jobs.