Ischemic stroke occurs due to a blockage of blood vessel flow caused by thrombus. One of elements that plays a crucial role in thrombus formation is fibrinogen. Multiple Slice Computed tomography (MSCT) scan is the main modality in diagnosing stroke. This study aims to evaluate brain infarction volume through non-contrast head MSCT Scan in various plasma fibrinogen level of acute ischemic stroke patient. This was a descriptive study with retrospective design conducted from July 2019 to February 2020 at Dr. Soetomo General Hospital, Surabaya, Indonesia. Sample of this study was ischemic stroke patients who met inclusion criteria. Data regarding plasma fibrinogen level was obtained through medical records. Brain infarction volume was measured using non-contrast head MSCT scan. There were 84 samples in this study. Infarction volume ranges from 1.64?350.35 mL. We divided the infarction volume into three groups: low, medium and high volume. Plasma fibrinogen levels ranges from 88.3 mg/dl to 723.4 mg/dl. The lowest and highest fibrinogen levels were found in low volume group. The highest mean value of fibrinogen levels (362.0 mg / dl) was in medium volume group, while the lowest (310.4 mg/dL) was in low volume group. Cerebral infarction volume through non-contrast head MSCT scan varied from 1.64 mL to 350.35 mL. Fibrinogen levels in acute ischemic stroke patients varied from 88.3 mg/dL to 723.4 mg / dL.