This study aims to find the prevalence and appearance of brain metastasis from CT and MRI in lung adenocarcinoma with negative and positive EGFR mutation status of exon 19 and 21, with evaluation parameters are location, numbers, presence of miliary lesion, largest size, component, contrast enhancement, and adjacent edema. A descriptive, retrospective study was performed on 119 lung adenocarcinoma patient with EGFR mutation status who underwent underwent head CT or MRI during January 2018 until December 2019. We found 19 (55.9 %) patients with positive EGFR mutation status of exon 19; 13 (48.1 %) patients with positive EGFR mutation status of exon 21; and 20 (37.0 %) patients with negative EGFR mutation status. The CT and MRI of patients with negative and positive EGFR mutation status of exon 19 and 21have similar appearance, with mos common location at corticomedullary, parietal lobe, multiple, with largest size 1.1-2.5 cm and 2.6 cm, solid-necrotic/cystic component, heterogenous ring contrast enhancement, and perifocal edema.