Looking into the prevalence of high level of macro and micronutrients malnutrition especially amongst the vulnerable sections in the country even at this time of dwindling economy and increasing prevalence of chronic degenerative diseases globally, the need for exploration of underutilized food parts is significant to overcome the nutritional disorders. Many seeds which we considered as waste and simply discard after taking the juicy part of the fruit may however be reservoir of many nutrients. The seeds of Citrullus lanatus (Watermelon) and Annona muricata (Soursop) were collected, dried and dehulled. They were thereafter pulverized and subjected to analysis to assess their nutritional qualities by identifying their essential amino acids and fatty acids. Results of the proximate analysis revealed that the seeds are rich sources of protein and fat. They also contain all the essential amino acids with leucine being predominant in watermelon and lysine in soursop. The seeds also contain essential fatty acids such as linoleic acids and linolenic acids. Overall, the results indicated that the seeds of watermelon and soursop are of high nutritional qualities as identified by the essential nutrients, hence, could be harnessed and incorporated in the diets (man and animal nutrition) to combat malnutrition.