Background: Female patients with clinical abdominal tumors generally undergo abdominal CT scan and serum CA-125 level examination. Thirty-three percent of patients with pelvic inflammatory disease and abdominal tuberculosis also had elevated blood CA-125 level. CT scan, which is an imaging modality with ionizing radiation, is important for diagnosing ovarian tumors. It is very common to find discrepancy between abdominal tumor?s preoperative diagnosis and postoperative diagnosis, which turns out to be abdominal tuberculosis. This study aims to determine the correlation between serum CA-125 levels with abdominal CT scan findings in abdominal TB resembling ovarian mass. Methods: This was a correlative analytic study with a retrospective approach which was conducted at Dr. Soetomo General Hospital, Surabaya. The sample of this study was medical records from all patients with abdominal tuberculosis who had undergone histopathological examination. Serum CA-125 levels, surgery, and histopathological examination data were obtained from medical records and statistical analysis was performed. Results: The distribution of the lesion extension degree varied, but most were included in moderate degree (59.1%). In terms of CA-125 level, most patients had significant increase (72.7%) of their CA-125 level. There was a negative correlation (rho = -0.096) which was not significant (p = 0.671 with ?=0.05) between serum CA 125-levels and the extension degree of abdominal tuberculosis lesion resembling ovarian tumors. Conclusion: There is a negative and insignificant correlation between serum CA-125 level and the degree of abdominal tuberculosis lesion extension resembling ovarian tumor.