Strategic alignment refers to the integration and coordination of applications of information technology and organizational goals. In this area, not only information technology programs should reflect goals, missions and business strategies, but business programs should also be referred to as an information technology program, applications and specific technologies It be. This research was conducted to evaluate the performance of small and medium Iranian businesses through strategic alignment and market response. In this research, the research variables were evaluated by a questionnaire. The questionnaire was distributed between 383 samples from the statistical population, which is all managers and experts of small and medium Iranian businesses. The research method was descriptive correlational. To answer the questions and examine the research hypotheses with SMART-PLS software, structural equation and path analysis was used by minor least squares method (PLS). The results of this study indicate that strategic alignment, factory technology capability, customization ability, delivery capabilities and cost control over company performance are positive and significant.