Smoking is a risk factor for disease that contributes the most to lung and respiratory diseases. Lung disease related with cigarette smoke can be classified as COPD (Chronic Obstructive Pulmonary Disease) and several types of interstitial lung disease such as pulmonary langerhans cell histiocytosis, bronchiolitis, desquamative interstitial pneumonitis and interstitial fibrosing lung disease. This literature review aims to shed a light that cigarette smoke not only causes inflammation and damages the epithelium of the large respiratory tract but also the small airways and lung parenchyma. COPD (including chronic bronchitis and emphysema) is one of the most common lung diseases and causes death due to smoking. Lung disease related with smoking in addition to providing a mass image can also provide an interstitial picture such as Langerhans cell histiocytosis, bronchiolitis, desquamative interstitial pneumonitis and interstitial fibrosing lung disease. Radiological overview in lung disease caused by cigarette smoke can also occur in combination. Although the radiological overview / image of computerized tomography can provide adequate information, a comprehensive diagnostic by combining clinical symptoms and histopathological features will be quite meaningful, especially for overlapping cases.