Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune condition with unclear cause that shows a broad ranging clinical symptoms, course and prognosis. Cerebrovascular illness, a severe symptom SLE in the central nervous system by neuropsychiatric SLE (NPSLE). Aphasia is considered to be one of the rarer signs, produced by secondary antiphospolipid syndrome (APS), of a cerebrovascular condition of NPSLE. Case: A 37 years-old married woman that has background of miscarriage in SLE with speech blocking, motor aphasia, and had nasal voice was diagnosed with NPSLE with APS. After initiating therapy with cyclophospamide and aspilet the patient?s clinical condition improved significantly. Conclusion: APS needs to bear in mind in SLE patients that has background of miscarriage or thrombosis. The diagnosis was based on history, clinical, and laboratory examinations which include phospholipid antibodies, There was dramatic improvement after 12 days of 500 mg of cyclophospamide and oral aspilet 100 mg daily therapy.