The phenomenon of teenagers today seems to want to look physically attractive, such as having white skin, smooth faces, and slim bodies. This phenomenon can create pressure for adolescents so that it is possible to tend to depression. Depression can be affected by factors of social support and self-esteem. The method used is quantitative, a sample of 110 girls. The measuring instrument used in this study was adapted from Beck's Depression Inventory, the Multidimensional Scale Of Perceived Social Support, and The Coopersmith Self Esteem Inventory. The results of the study simultaneously showed that there was an effect of social support and self-esteem on the tendency of depression in adolescent girls of 0.000 (p?0.01) with an R Square value of 38.6%. This showed that the hypothesis is accepted is that there is an influence of social support and self-esteem on the tendency of depression in adolescent girls by 38.6% and 61.4% influenced by other factors. In addition, the effect of social support on the tendency of depression in adolescent girls has a significant effect of 0.021 (p?0.05) with an R Square value of 4.9%. Self-esteem on the tendency of depression in adolescents shows a significant effect of 0.000 (p?0.01) with an R Square of 37.6%.