Background: Nasopharyngeal carcinoma is a malignancy shows squamous differentiation, incidence rate was 5% in Indonesia. Eosinophils are granulocytic leukocytes residing in blood and tissues, has been related as a prognostic indicator for cancers. Whether an increase in eosinophils leading to favorable or unfavorable prognosis still remains controversial and depends on many factors including the type of cancer. Objective: This study was aimed to analyze correlation the presence of eosinophil with histopathologic subtypes in nasopharyngeal carcinoma Material and Methods: This study was analytic, with cross-sectional approach, which were enrolled 72 slides of NPC biopsy, and assessed by accounting eosinophils in 10 high power field (HPF) with 40X magnification. The result with 0 is nothing eosinophil, 1-4 is mild infiltration, 5-19 is moderate infiltration, ?20 is severe infiltration. Result: There were more males than females, with the highest age group being 51-60 years and the most common histopathological subtype was non-keratinizing squamous cell carcinoma (NKSCC). In NKSCC subtype, the most common eosinophil infiltration category groups were mild and moderate infiltration as many as 25 (39.7%) samples, and in keratinizing squamous cell carcinoma (KSCC) subtype the most common samples were obtained in mild infiltration category group 5 (55.6%) samples. Mann Whitney U test was performed on this variable and obtained p-value 0.025 (p ? 0.05). Conclusion: There was correlation between presence of eosinophil with histopathological subtypes in nasopharyngeal carcinoma.