Background: Mother-to-child transmission of hepatitis B virus makes a significant contribution to chronic hepatitis B virus infection. One strategy to prevent hepatitis B transmission from mother to child is by administering hepatitis B immunoglobulin (HBIg) and hepatitis B vaccination. Methods: This meta-analysis used secondary data from articles taken from 2000 to 2020 through the PubMed database, Google Scholar. There were 5 articles for antiHbs and 4 articles for HBsAg that matched the inclusion and exclusion criteria. Analysis using the Revman Review Manager 5.4. Results: The comparison of the proportion and confidence interval on HBsAg and anti-HBs status after hepatitis B vaccination in infants of HBsAg positive mothers showed that anti-HBs results with a combined effect magnitude of 0.89 (95% CI 0.83; 0.94), p < 0.05 while HBsAg status with a combined effect of 0.09 (95% CI 0.03; 0.015), p < 0.05. Conclusion: The successful proportion of hepatitis B vaccination with HbIg is 89% and HbsAg positive status in infants is 9%.