Background: Endometrial cancer is the most common gynaecological malignancy with an increasing incidence. The survival rate is related to the histological type of the tumor including grade. Tumor budding is defined as single cells or clusters of up to four cells at the margin of the tumor front. This phenomenon is regarded as a histological basis of metastasis formation and further tumor invasion. Methods: This is an analytical study with cross sectional approach on 38 resection specimens from the patients diagnosed as endometrial cancer stained with Hematoxylin & Eosin. The statistical analysis was performed by using Chi-square test to analyze the correlation of tumor budding index and histological grading in endometrial cancer. Results: The identification of 38 samples of endometrial cancer patients found that the mean age of the patients was 55,5 years with a minimum age of 31 years and a maximum age of 84 years, the most common age group was > 55 years (52,6%), the most frequent distribution was low budding (57,9%), low grade histopathological (68,4%) , and there was a significant correlation between the tumor budding index and the histopathological grade (p=0,002).