At the time of transition from early adolescence to late adolescence, individuals produce changes in the term of social and emotional within themselves. The aim of this research was to determine whether there was an effect between Empathy, Emotional Intelligence on Interpersonal Communication at X University Students. The participants in this research were 101 students at X University. The data analysis technique used multiple linear regression. Then, simultaneously empathy and emotional intelligence had a significant correlation with interpersonal communication. Empathy is an important communication skill that has been proven to affect individual emotional intelligence and interpersonal communication