Fournier gangrene is a rare type of necrotizing fasciitis which affects the perineal, genital, or anorectal region. It is considered as a urological emergency as it has a high mortality rate, at 20 to 50% in most reported series. Our aim was to evaluate the role of neutrophil-lymphocyte ratio as a prognostic marker for Fournier gangrene patients. There is an increasing interest in suggesting the correlation between inflammatory status and disease prognosis, one of the most commonly used parameter is the neutrophil-lymphocyte ratio (NLR). This is an analytical study with a retrospective approach evaluating the medical record data of patients diagnosed with Fournier gangrene admitted to Dr. Soetomo General Academic Hospital from January 2012 to November 2020. A total of 109 patients aged approximately 50.31 years old were included in this study. The average NLR of the patients was 15.86, indicating a high NLR compared to the ratio found in healthy people. The area under curve value was 0.65 (95% CI; 0,524-0,754; p < 0,05). The Kaplan-Meier curve in figure 2 showed that the NLR cut-off value of 10.9 has a significant impact on the patient?s mortality rate (95% CI ; 29,7-19,7; p < 0,05). This study revealed that NLR can be used as an indicator of poor prognosis in FG patients with a cut-off point value of 10.9.