Currently, many people are experiencing psychological problems, including students, and the number is increasing. However, there are still many who are reluctant to seek professional help. This can be caused by internal factors such as self-stigma and external factors such as social support. This study aims to examine the effect of self-stigma and perceived social support on help-seeking behavior from professionals. The research participants were 436 undergraduate students at universities in the Greater Jakarta area, Indonesia, and were obtained using the snowball sampling technique. The measuring instruments used in this research are Attitudes Toward Seeking Professional Psychological Help-Short Form (ATSPPH-SF), Self-Stigma of Seeking Help (SSOSH), and Multidimensional Scale of Perceived Social Support (MSOPSS). The analysis was performed using a multiple linear regression test. The results show that together self-stigma and perceived social support have a very significant effect on help-seeking, and the magnitude of the effect is 26.8%. As for the influence of each variable, self-stigma has a very significant effect on help-seeking, while perceived social support does not have a significant effect on help-seeking. This means that participants, efforts to seek help when experiencing psychological problems, are more influenced by how stigmatized they are. The existence of stigma against themselves will prevent participants from seeking professional help when experiencing psychological problems.