Background and Purpose: The executives patients with ceaseless stroke created to treatment that fast and exact on target can reduce morbidity rate patients with strokes. In intense ischemic stroke, irritation process came about in neutrophil cells preparation as the main leucocytes coming through in the ischemic region. This review meant to correlation between changes in neutrophil levels and clinical result in patients with intense ischemic stroke < 72 hours and the 7 days beginning at Dr. Soetomo medical clinic. Method: A cross-sectional technique was utilized in this study. Test information were gathered from the stroke library in the neurologic room at Dr. Soetomo medical clinic from January to March 2021. Neutrophil level were gathered upon <72 hours and 7 days of beginning. The information were surveyed utilizing National Institutes of Health Stroke Scale (NIHSS) upon release. Information was dissected utilizing SPSS rendition 24 with p<0.05 as huge worth. Result: From the stroke library information, it was observed that 65 subjects have satisfied the measures for this review. In the comparison of neutrophil levels and NIHSS scores on onset <72 hours NIHSS scores were found in moderate NIHSS 14 subjects (21,5%) with a mean neutrophil of 8.62 ? 2.5 x103/uL statistically significant with p = 0.015, while the after 7 days onset results of increased neutrophils were found in moderate NIHSS 18 subjects (27,7%) with a mean neutrophil of 8.03 ?3.2 x103/uL. The difference results were found to be statistically significant with p = 0.037. Conclusion: There is a significant difference between changes in neutrophil levels and clinical outcome in patients with acute ischemic stroke < 72 hours and the onset of day 7, that the higher the neutrophil level, the worse the clinical outcome of stroke