Stroke is a disease that become a problem in the world, because it is the second leading cause of death after heart disease. Risk factors for stroke such as diabetes mellitus, hypertension, dyslipidemia, smoking can cause a thrombotic process that begins with damage to the endothelial lining of blood vessels. Hypertriglyceridemia and hyperglycemia are common risk factors for stroke. There are various mechanisms that cause stroke, one of which is insulin resistance. This insulin resistance can initiate the atherosclerotic process, which if it occurs in the brain can cause a thrombotic stroke. A simple and easy method of measuring insulin resistance is to assess the glucose triglyceride index (tyg index). The wider the atherosclerotic process in the blood vessels of the brain, the more severe the stroke patient will be. Stroke severity was assessed by the National Institutes of Health Stroke Scale (NIHSS). The NIHSS has several degrees of severity where the outcome is often used. This study assessed the relationship between the glucose triglyceride index and the severity of thrombotic stroke as assessed by the NIHSS. The results obtained from this study were significant with p=0.022 (p<0.05). However, this relationship is weakly correlated with a correlation coefficient of 0.283.