Background: Pediatric Logistic Organ Dysfunction 2 (PELOD-2) score is the score for organ dysfunction that currently recommended in critically ill children. Laboratory markers that can describe the presence of organ dysfunction in bacterial infections, such as neutrophils, lymphocytes, neutrophil/lymphocyte ratio (NLR), platelet, red blood cell distribution width (RDW), C-Reactive Protein (CRP) and procalcitonin (PCT). Objective: to determine the relationship between neutrophil, lymphocyte, NLR, platelets, RDW, PCT, and CRP with organ dysfunction based on PELOD-2 scores in critically ill children. Methods: Analytical analysis with cross sectional approach in critically ill patients age ? 1 month to 18 years treated at the High Care Unit (HCU) and Pediatric Intensive Care Unit (PICU), Haji Adam Malik General Hospital, Medan, from November 2020 ? February 2021. Assessment of PELOD-2 scores as well as neutrophil, lymphocyte, NLR, platelet, RDW, PCT, and CRP were conducted within 24 hours after patient was admitted. Results: A total of 52 subjects were analyzed. Neutrophil, lymphocyte, NLR, platelet and RDW values measured in the first 24 hours had no correlation to PELOD-2 scores in critically ill children. PCT and CRP values measured in the first 24 hours had a positive correlation to PELOD-2 scores in critically ill children (r = 0.463, p = 0.001 for PCT and r = 0.320, p = 0.021 for CRP). Conclusion: PCT and CRP values measured in the first 24 hours were correlate with organ dysfunction based on PELOD-2 scores in critically ill children.