The study aims to describe the impact of spirituality on the mental health of pregnant women. In this study uses a literature review method using a comprehensive strategy such as searching for articles in a research journal database. Article search uses Pubmed/MEDLINE and Springer Link in the time of frame (2016-2021). The keywords used in the search were Spirituality, Mental Health and Pregnant Women. There were 233 articles obtained, and 7 articles were analyzed through the purpose, suitability of the topic, sample size, research protocol, and the results of each article. The results of the study indicate that there is a significant effect of spirituality on the mental health of pregnant women, such as; reducing stress, decreasing fear of birth, increasing a sense of happiness and helping mothers control emotions and communicate them with people around them.