Excessive opioid usage such as codeine can lead to anxiety, dose dependency, and addiction. Furthermore, drug addiction induce intoxication and in some case death. Several approach can be done to treat codein abuse. Hyberbaric oxygen is one of the therapy choices, considered that it can be used as main and supporting management. Related studies said increasing level of Nitric Oxide (NO) and Dopaminergic, main substances in drug addiction, can be inhibited by hyperbaric oxygen therapy thus it has the potential value to reduce narcotic addiction such as codeine. However, the review papers of previous research is rare. Therefore, this article discussed codeine, hyperbaric oxygen therapy (HBO), and its relation to decrease level of codein addiction, based on scientific literatures. In conclusion, HBO treatment has a potential correlation to minimize the effects of opioid withdrawal, since it can induce nitric oxide and involves the control of monoaminergic neurotransmitters that reduce withdrawal effects.