Implant is widely used to correct deformation, to stabilize fracture site, and promote bone healing in several orthopaedic surgeries. The use of implant is usually having a higher risk of developing infection. Although the use of antibiotic prophylaxis and antimicrobial impregnated biomaterial are used in cases of surgeries. But, the emerging superbugs which resistant to antibiotics, biofilms formation, and chronic immune suppressing diseases and lifestyles are challenging issues to make good osteosynthesis. Author use orthopaedic implant related infection to explain about the infection associated with the use of orthopaedic implants. This article attempts to discuss about infection associated with orthopaedic implant surgeries and treatment possible to treat the infection during implant placement.