Endoscopic variceal obturation with tissue adhesive injection is a mainstay treatment to control gastric variceal bleeding. We looked into the side effects and risks that come with this treatment in a subject. Therefore, this study aimed to evaluate and present a case study of this type of complication. A retrospective complications analysis was performed of a 57-year-old male patient with gastric variceal hemorrhages who was admitted to tertiary care. The patient received N-butyl-2-cyanoacrylate as therapy for endoscopic variceal obturation. Four days past the surgery, the patient experienced recurrent and uncontrolled massive hematemesis and later died of uncontrollable bleeding. This report concludes that although complications from endoscopic variceal obturation with Histoacryl glue N-butyl-2-cyanoacrylate in the treatment of gastric varices are uncommon, they may still occur.