The main objective is to ascertain the direction and magnitude of the relationship of the variables that may have a bearing in the poverty reduction efforts in Northern Mindanao, that is, Region 10, Philippines. These variables were as follows: Gross Regional Domestic Product (GRDP), Population, Employment, and Poverty Incidence. The significance of this approach is to shed light on the developmental trend of previously and recently formulated policies, programs, and projects relative to poverty alleviation efforts in Northern Mindanao. Applying Path Analysis via Regression, the causal connections of these variables were tested using panel data from 2003 to 2018. The findings have shown that Population has a direct influence on GRDP while Employment has no direct influence on Poverty Incidence. GRDP, on the other hand, has a direct influence on Employment and Poverty Incidence but has no indirect influence on Poverty Incidence through Employment. While Population has a direct influence on Poverty Incidence but no indirect influence on Poverty Incidence through Employment. The study concluded that the direct influence of GRDP on Poverty Incidence is negative while the influence of GRDP on Employment; Population to GRDP; and Population to Poverty Incidence were all positive. Overall, the study, therefore, recommends that in the conceptualization and development of policies, interventions programs, and projects relative to poverty reduction and their consequent impact evaluation, such should take into account how the policies, programs, and projects have influenced a significant change of the relationship of these variables as seen in a period of fifteen years.