This study focuses on investigating the Challenges in an Online Business Faced by the Junior and Senior High School Student-Entrepreneurs in Philippine School Doha, S.Y. 2021-2022. Specifically, it describes the (1) products and services the respondents provided in their online business and the (2) challenges in an online business encountered by the respondents. The study utilized the quantitative descriptive research design and made use of a validated self-made survey questionnaire. Twenty (20) Junior and Senior High School student-entrepreneurs were purposely selected as respondents of the study. The challenges in an online business included computer related skills and expertise, developing customer-owner relationship, management of finance and accounting, health and safety repercussions, limitations of business types, and privacy and security concerns. Results of the study showed that the commonly faced challenges are developing customer-owner relationships which pertains to the consumer and entrepreneur interaction which may affect the buying behavior or loyalty of the buyer, and health and safety repercussions which tackles safety measures the entrepreneurs take during production and delivery of goods to the consumer. It is therefore recommended that student-entrepreneurs or future student-entrepreneurs may recognize the challenges that they may encounter while handling an online business in order to have the capacity to adapt to the growing market. Keywords: Student-Entrepreneur; Online Business; Products and Services; Computer related skills and expertise; Developing customer-owner relationship; Management of finance and accounting; Health and safety repercussions; Limitations of business types; Privacy and security concerns