The three primary causes of maternal mortality are beginning to alter, including hemorrhage, pregnancy-related hypertension, and novel reasons, such as cardiac illness during pregnancy, one of which is peripartum cardiomyopathy. The pathophysiology of preeclampsia and cardiomyopathy may be observed. sFlt-1 generated in excess by the placenta may result in preeclampsia and/or PPCM. This may be recognized in preeclampsia and PPCM by cardiovascular alterations and echocardiographic characteristics.