Regardless of the fact that vaccination saves millions of lives each year, vaccine hesitancy on COVID-19 still affects a sizable portion of the population in the world, including the Philippines. The differences in COVID-19 vaccine hesitancy among students at PHINMA Saint Jude College in both non-health and health professions were investigated in this study. Four indicators were identified and used: knowledge of COVID-19, social factors, health-related factors, and geographical factors. A quantitative-descriptive study was conducted to see if there is a difference in how students from non-health and health professions perceive vaccine hesitancy to COVID-19. The data gathered were analyzed using SPSS. The Mann-Whitney U test, weighted mean, and simple percentage were performed. Lastly, statistical differences were accepted when p-values were < 0.05.?Only 274 of the survey responses were analyzed in this study. The results show that 99.3% of the gathered participants were already vaccinated, compared to 0.7% who were still hesitant to be vaccinated. The findings also showed that knowledge of COVID-19 (p = 0.004), social factors (p = 0.042), health-related factors (p = 0.015), and geographical factors (p = 0.033) influenced the respondents? COVID-19 vaccination. The outcomes implied that all these factors influencing vaccine hesitancy, which had p-values < 0.05 level of significance, significantly differed among students in non-health and health professions.?COVID-19 vaccine hesitancy is expectedly low among students in health professions compared to students in non-health professions, and it is significantly influenced by COVID-19 knowledge, social factors, health-related factors, and geographical factors.