The hematology and serum biochemical parameters of seventeen (17) healthy West African Dwarf goats (WAD) consisting of ten (10) gravid and 13 non-gravid does were assessed. The animals weighed between 15 to 25kg with ages ranging from 18 to 30 months and were managed under a semi-intensive system. The whole uncoagulated blood and serum were sampled from each of the does. Only the Red blood cell (RBC) and white blood cell (WBC) counts among the hematological parameters showed a significant (p<0.05) difference both of which are higher in the pregnant does (13.93 x 1012/L; 25.27 x 109/L) than in the non-pregnant (9.06 x 1012/L; 16.51 x 109/L. The urea increased (4.64mg/dL? 0.19 to 4.77mg/dL ? 0.08) significantly (p<0.05) while the calcium decreased (2.56 mmol/dL ?0.07 to 2.49 mmol/dL0.03) significantly (p<0.05) in the pregnant does. No observable significant differences (p>0.05) were obtained among the other determined biochemical parameters, namely sodium (Na), potassium (K), Phosphorus (P), bicarbonate (HNO3); Total protein (Tp), Glucose (Glu), Albumin (Alb), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Alkaline Phosphate (ALP). These results conclude that hematological and mineral imbalances are unlikely to occur in normal healthy pregnant WAD goats when properly managed while the difference in a few parameters recorded in the gravid and non-gravid suggests the increased activities and nutritional requirement and not the ecological influences.