Breast cancer is a chronic disease with high mortality, cancer patients can experience various problems including physical, psychological and spiritual problems, such as stress, sadness, physical fatigue and fear of the future, and all things will affect the quality of life of patients. Humans have a holistic nature that is both physical and psychological beings that influence each other, so that what happens with physical conditions will affect psychologically, to overcome this one of the factors that can be done to improve or affect the quality of life of breast cancer patients is self compassion, perceived social support, and self esteem to quality of life on woman affected breast cancer. The study participants were woman affected by breast cancer (N = 37). Data were analyzed by multiple regression analysis. The result show that there is an influence between self compassion, perceived social support, self esteem to quality of life which is very significant with a significant value of 0.000