The platelets-lymphocytes ratio (PLR) is one of the inflammatory markers of atherosclerosis. Atherosclerosis is common among patients with compromised immune systems, including those with systemic lupus erythematosus (SLE). The occurrence of atherosclerosis at an early age (accelerated atherosclerosis) will increase the mortality and morbidity of SLE patients. The aim of this study was to assess the relationship between PLR and carotid intima-media thickness (CIMT) in patients with SLE. A cross-sectional study was carried out at Dr. Zainoel Abidin Hospital, Banda Aceh from July to December 2020. The PLR was determined by dividing the platelet count by lymphocyte count using a calculator during regular hematological examinations, while CIMT was measured using B Mode Doppler ultrasonography (USG). Other hematological parameters such as hemoglobin, hematocrit, erythrocyte, leucocyte, and diff count were also evaluated. Data analysis was performed using SPSS software. Fisher?s exact test was employed to determine significant association between PLR and CIMT, and p < 0.05 was considered statistically significant. A total of 33 SLE patients were enrolled in the study 2 of them (6%) showed an increased CIMT, with an average age of 53.5 ? 2.12 years and diagnosis duration of 78 (12-144) months. Increased PLR was observed in 54.5% (18) of the patient, where one of them was noticed the thickening of the carotid intima-media as well. However, the result of Fisher's exact analysis suggested no significant relationship between PLR and CIMT in the patients with SLE (p = 1,000).

platelet to lymphocyte ratio

Atherosclerosis

tunica intima thickness

systemic lupus erythematosus