The study aimed to utilize online applications in crafting and embedding Most Essential Learning Competency (MELC) based Science 7 lessons, activities, and quizzes on a website. The researcher followed the Analysis, Design, Development, Implement, Evaluate (ADDIE) model, a systematic approach to instructional development. The quasi-experimental method was employed; the dependent variable was measured once before the treatment was implemented and once after the treatment was implemented. Through the developmental and quasi-experimental methods, the clarity, adequacy, suitability, and user-friendliness of the Science website were determined. Pre-test and post-test were administered to determine whether the utilization of developed online applications on the Science website influenced the performance of students. The findings showed that the developed online applications on the Science website had very clear adequate content, attaining a very high remark on the overall mean based on the ratings of Science teachers and TLE/ICT teachers. Likewise, a very high remark was also obtained for the suitability and user-friendliness of the instructional design of the Science website. Meanwhile, the data also showed that the grade 7 online distance learners? mean performance increased after using the website. No significant difference in the ratings of Science teachers and ICT/TLE teachers on clarity, adequacy, suitability, and user-friendliness of the developed online applications on the Science website was found. However, regarding the pre-test and post-test results, the test scores of the grade 7 ODL learners have a significant difference. To further improve the study, it is recommended to use the experimental method rather than the quasi-experimental to test the effectiveness of using the developed online applications on the Science website. Also, each quarter?s pre-test and post-test be obtained to analyze comprehensively the specific website?s subpage that needs to be improved. Furthermore, studies about online applications that are suitable to the demand of the lesson presented are recommended. This is to improve the website?s instructional design in terms of suitability.