Background: Adenocarcinoma of the prostate is an invasive carcinoma, a neoplasm of prostate epithelial cells with secretory cell differentiation. Histomorphology is glandular. The cells are sheets or single cells with neoplasia, basal cells are not seen in this carcinoma. Tumor-Infiltrating Lymphocytes (TILs) are lymphocytes that migrate to tumor cells or peritumoral cells. In a malignancy, T lymphocyte infiltration can be found, indicating an immune response to malignancy. The cluster of Differentiation 5 (CD5) is a transmembrane receptor that plays a role in regulating the function and development of T cells. Objective: To determine the correlation between Immunohistochemical expression of Cluster of Differentiation 5 (CD5) and the Stromal Tumor-Infiltrating Lymphocytes (sTILs) grade in Prostate Adenocarcinoma. Material and method: This study was conducted on slides of 32 prostate adenocarcinoma patients. Each slide was stained with hematoxylin and eosin (H&E), and the grade of STILs was observed on the slide. Furthermore, CD5 immunohistochemical staining was carried out to see and analyze whether the appearance was positive or negative. Findings: Among 32 specimens of prostate adenocarcinoma patients, it was found 10 mild STILs, 22 moderate STILs and no severe STILs on hematoxylin and eosin (HE) staining, CD5 immunohistochemical staining was obtained 16 positive expressions and 16 negative expressions. Conclusion: There is no correlation between immunohistochemical expression of Cluster of Differentiation 5 (CD5) and the grade of stromal Tumor-Infiltrating Lymphocyte (sTILS) in prostate adenocarcinoma. .