Backgrounds: Cempedak is an endemic plant in Indonesia and its leaf has potential action as a sunscreen because it contains flavonoid compounds that have photoprotective effect because it can absorb ultraviolet. This study to prove the effect of cempedak (Artocarpus champeden) leaf extract cream compared with zinc oxide (ZnO) cream in decreasing TNF-? level and sunburn cells from the epidermis of rats (Rattus norvegicus) exposed to ultraviolet B (UVB). Methods: The research was an experimental study with a randomized post-test only control group design. The research subjects were 36 male wistar rats (Rattus norvegicus), which were divided into 2 groups: group I was 18 rats were given10% ZnO cream before exposured to UVB, and group II was 18 rats were given 4% Artocarpus champeden leaf extract cream applied 30 minutes before exposured to UVB. TNF-? was measured with ELISA, and sunburn cells was evaluated in histology slide from skin biopsy. The statistical analysis to compare the effect of both creams was using an independent t-test. Results: The mean TNF-? level in group I was lower than in group II (347.51?67.06 ng/L vs 782.38?174.44 ng/L; p<0.001). Sunburn cell were also lower in group I compared to group II (1.30?0.96 vs 2.30?0.96; p=0.024). Conclusion: Topical cream cempedak leaf ethanol extract (Artocarpus champeden) 4% decreased TNF-? level and sunburn cells in the epidermis of male Wistar (Rattus norvegicus) rat exposed to ultraviolet-B radiation