Introduction Osteosarcoma is the most common non-hemopoietic primary bone malignant tumor. Surgery is a fundamental component of any osteosarcoma treatment algorithm. Amputation is indicated because of the involvement of multiple neurovascular bundles or the presence of soft tissue involvement. Amputation can affect the patient's quality of life. The method with LSS has better results than amputation. The quality of life of patients with osteosarcoma is determined by the therapeutic measures they undergo and the emotional quality of the patients in their post-therapy life. In this study, we observed the clinical outcome of osteosarcoma patients undergoing amputation using an SF-36 score. Methods This cross-sectional study took data from medical records from 2013 ? 2018. Patients with osteosarcoma who underwent amputation surgery were included in the sample of this study. The inclusion criteria in this study were patients who had undergone above knee amputation (AKA) surgery. Exclusion criteria in this study were incomplete patient medical record data, the patient could not be contacted/contacted, the patient was sick/died, and the patient did not complete the questionnaire. Results This study was carried out from 2013 ? 2018, and 36 patients were included with an average age of 24.23 ? 12.71. Patients included in this study consisted of 26 (73%) males and 10 (27%) females. The quality of life of osteosarcoma patients was assessed using the SF-36, which assessed the physical and mental components. The results of the SF-36 assessment in this study obtained the total value of the physical component, 49.76?14.33, and the total value of the mental component, 49.01 ? 14.67. Conclusion This study showed quality of life of osteosarcoma patients with amputation treatment showed low results in this study