In general, prostitutes who are in panti sosial often feel that their lives are less meaningful. Therefore, intervention is needed to increase the meaning of life. The purpose of this study was to determine the effectiveness of logotherapy intervention in increasing the meaning of life in prostitutes in Panti Sosial X. This study used a quasi-experimental method in the form of a one group pretest-posttest design. The results showed that there was a significant increase in the meaning of life before and after the intervention with logotherapy. The dimension of seeking the meaning of life shows a greater increase, than the dimension of the emergence of meaning in life. Based on the results obtained, it can be concluded that logotherapy intervention is effective in increasing the meaning of life for prostitutes in Panti Sosial X. These results can also be a recommendation regarding the need for routine logotherapy interventions for prostitutes in social institutions.