Systemic Lupus Erythematosus (SLE) is an autoimmune illness with a broad range of clinical manifestations, one of which is hematological manifestations that cause high morbidity and mortality if there is a delay in diagnosis. This research was conducted to analyze the pattern of hematological manifestations of SLE patients. This research was a descriptive retrospective study. A total of 106 patients with systemic lupus erythematosus met the inclusion criteria. Patients were dominated by a female (94.34%) and the age group of 18 - 27 years old (46.23%). The average hemoglobin level of the sample was 8.16 g/dl with anemia in 99 patients (93.4%), which was morphologically dominated by normochromic normocytic anemia in 61 patients (57.55%). The mean platelet count of the sample was 192.77 x 10³ /µL and thrombocytopenia was found in 26 patients (24.53%). The mean lymphocyte count of the sample was 1.03 x 10³ /µL and lymphopenia was found in 26 patients (79.25%). The mean leukocyte count in the sample was 7.53 x 10³ /µL and leukopenia was found in 22 patients (20.75%). This study concludes that SLE patients are dominated by females aged 18 – 27 years old and the most frequent hematological abnormalities are anemia (morphologically dominated by normochromic normocytic anemia), thrombocytopenia, lymphopenia, and leukopenia.