Introduction: Discovering the best approach in the management of myopia control is the main objective of several studies. Nowadays, different strategies are carried out to prevent myopias development and reduce its progression, such as low-dose atropine eye drops, optical devices including multifocal spectacles and multifocal contact lenses, and orthokeratology (Ortho-K). This paper aims to compare the efficacy of the combination of different treatments for myopia control to the prescription of a single treatment. Methods: Studies related to the purpose of this review have been researched mainly on PubMed. Literature research using the database yielded 419 papers, 9 of which were analyzed and compared in this review. Results: A large number of studies is present in the literature concerning the effectiveness of combined therapy compared to monotherapy for the control of myopia progression. In this revision, four studies on the efficacy of low-dose atropine combined with optical devices were selected and also five studies on the combination of atropine with Ortho-K. Conclusion: Most results indicate that combination treatments offer better myopia control efficiency than some monotherapy strategies, but further research on etiology and management of myopia is needed to prevent its development.