Graves disease is an autoimmune disorder affecting the thyroid gland with a wide range of clinical manifestations. One of the most notable signs of Graves disease is hyperthyroidism. In general, there are three options in treating Graves hyperthyroidism: pharmacological therapy, thyroidectomy, and radioactive iodine therapy. Thionamides, which consist of methimazole, carbimazole, and propylthiouracil, are considered to be the most prominent pharmacological therapy of Graves disease. Among these drugs, propylthiouracil is the least favored because of its adverse effects.

propylthiouracil

carbimazole

Graves Disease

Methimazole

thionamides