Pediatric optic neuritis (PON) tend to have their differences with adult optic neuritis (ON). It might happen due to several etiologies such as neuromyelitis optica disorder, acute disseminated encephalomyelitis, multiple sclerosis and many more. While cases of post infectious and post vaccination rarely happened in adults compared to other etiologies, it works differently on pediatric cases. Pediatric ON caused a lot by post infectious and post vaccinations episode, and may or may not associated with other etiology. Vaccines are a must have thing to do in childhood period, therefore it is crucial to know more about post vaccinations PON. This article aims to review previous studies discussing pediatric optic neuritis especially the ones due to post vaccination.