The beauty of culture has remained unchanged over the years. Cultural diversity has generated problems which until now, are yet to be solved with a suitable one-fit-all solution among partners in the international business. The aim of this study was to: (1) Examine how business culture affects negotiations between business delegate of Nigeria and UK; and (2) Ascertain the nature and extent of differences between the business culture of UK and Nigeria. Findings revealed that:  Significant differences existed between the business culture of Nigeria and UK, and these differences impacted negatively on business negotiations among delegates from the countries. As a result, managers are constantly faced with the challenges of managing cultural diversity arising from mixed culture of UK and Nigeria. The study concludes that the business cultures of Nigeria and UK have much incompatibility, and this will always engender lots of hitches in business negotiations among business partners that lack knowledge of varying business culture. However, proper enlightenment of business partners on obvious differences in cultures of UK and Nigeria was recommended as a way out of the quagmire.