Low back pain (LBP) is one of the most common complaints of pain in the settings of primary care. It affects the posterior region of the trunk that surrounds the first to fifth lumbar spine posteriorly. One of the most common mechanisms of LBP is excess muscle use in the posterior lumbar region that can promote the activation of nociceptors and cause pain. There are many risk factors that may lead to LBP which are classified into three types: individual, psychosocial, and occupational. One of the psychosocial risk factors of LBP is psychological stress. Based on the review over previous articles, psychological stress plays a role in the occurrence of LBP through excess cortisol and pain perception. There are also studies that stated a strong correlation between psychological stress and LBP.