Background: Burnout is a symptom of emotional exhaustion, cynicism, and fatigue that occurs in an individual who does work by providing a form of service to others or the like. Burnout has the possibility of happening to students even though professionally students are not considered to be working or not having a job. Objective: This study aims to determine the prevalence of burnout syndrome based on the year of lecture and to determine academic and non-academic factors that influence the occurrence of burnout syndrome in medical students. Method: This study is a cross-sectional with respondents from the Medical Study Program, Faculty of Medicine, Airlangga University in the 2019-2021 class. The sampling technique was carried out by consecutive sampling. Data collection using a questionnaire. Instrument used is a burnout scale questionnaire made by Freudenberger and Richelson which has been translated into Indonesian Results: The results showed that 136 medical students had filled out the distributed questionnaires. The total number of students affected by burnout is 71 people with a percentage of 52.2%. In this study, the academic and non-academic factors that were found to have a significant effect on the occurrence of burnout in students were the average lecture time (p-value = 0.011), study fatigue (p-value = 0.038), and free time (p-value = 0.037) through logistic regression. Conclusion:  There is a correlation between the incidence of burnout with the variable duration of daily lectures, study fatigue, and free time.