Stress, anxiety, and depression are common psychological disorder reported among medical students worldwide. During the COVID-19 pandemic era, medical students are burdened with high academic demand and pressure, despite the quarantine and limitations. Such psychological disorders are frequently found in undergraduate students, especially in medical students, which could lead to more problematic mental health issues and may affect professionalism and, ultimately, patient safety and care. This article reviews the risk factors associated with stress, anxiety, and depression among medical students during the COVID-19 pandemic. Abundant literatures were found related to this topic, but only a few important and informative research articles were included in this review. This review provides a bigger picture of the current psychological condition among Indonesian medical students. Medical students in Indonesia had varying levels of stress, anxiety, and depression with various associated academic and non-academic risk factors.